The purpose of epidemiological monitoring is to improve the prevention and treatment of congenital malformations. In Yakutia, the prevalence of congenital malformations is recording in Register of Medical Genetic Center, Republican Hospital №1 - “National Medical Center”. Introduction: Congenital malformations represent an urgent problem that affects the structure of infant and child mortality. Ammosov North-Eastern Federal University, Yakutsk, Russian Federation, 2Medical Genetic Center, Republican Hospital №1 – “National Medical Center”, Yakutsk, Russian Federation Maksimova 1 1Research Laboratory “Molecular Medicine and Human Genetics”, Medical Institute, M. E-P01 Reproductive Genetics/Prenatal GeneticsĮ-P01.07 Epidemiological monitoring of congenital malformations in Yakutia from 2007 to 2018 A.