It used established quantifications of sarcomere and T-SR anatomy (radial diameter \(d=220 \, \mathrm\). A finite element analysis modelled diffusional generation of steady-state Ca 2+ microdomains within skeletal muscle transverse (T)-tubular-sarcoplasmic reticular (SR) junctions, sites of ryanodine receptor (RyR)-mediated SR Ca 2+ release.
